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Information on the use of VITAMIN E VAGINAL SUPPOSITORIES comes from Ant (DIABETIC VULVOVAGINITIS TREATED WITH VITAMIN E SUPPOSITORIES. Am J OB GYN 1954 67:407-10), whose clinical results with 24 cases of vulvovaginitis showed an excellent response to VITAMIN E suppositories. He surmised the action of the Vitamin E was to increase the barrier against infection and stimulation of normal vaginal mucosa and vulvae skin. He theorizes that both diabetic and senile vulvovaginitis are symptoms of Vitamin E deficiency and replacement would correct the condition. Anecdotal experience of alternative practitioners with Vitamin E suppositories in atrophic (senile) vaginitis is positive. For women in whom estrogen replacement therapy is contraindicated, or for those patients who choose not to use estrogen, Vitamin E Suppositories can provide a viable alternative for relief of vaginal dryness.